lxd123456
Prof. Member
Geregistreerd op: 05 Jul 2018
Berichten: 2876
|
 Geplaatst: 12-01-2019 03:16:49 Onderwerp: [url=http://www.cheapcollgencaajerseys.com/] |
 |
|
WASHINGTON， Oct. 12 (Xinhua) -- Scientists said Wednesday they have used a popular gene-editing tool to successfully fix a genetic mutation that causes sickle cell anemia， taking a key step toward a cure for the blood disease.
As described in the U.S. journal Science Translational Medicine， the researchers used CRISPR-Cas9 to correct the disease-causing mutation in stem cells from the blood of affected patients.
Only "a proportion" of stem cells were fixed and produced healthy hemoglobin， but that is "high enough to produce a substantial benefit in sickle cell patients，" they said.
When implanted into mice， these corrected stem cells stuck around for at least four months， with no signs of side effects， a hint that they would also work in humans.
"This is an important advance because for the first time we show a level of correction in stem cells that should be sufficient for a clinical benefit in persons with sickle cell anemia，" said co-author Mark Walters， director of Benioff Oakland's Blood and Marrow Transplantation Program at the University of California (UC)， San Francisco.
Senior author Jacob Corn， scientific director of the Innovative Genomics Initiative at UC Berkeley， said they hope to re-infuse patients with the edited stem cells and alleviate symptoms of the disease.
Corn and Walters will work together to initiate an early-phase clinical trial to test this new treatment within the next five years.
"There is still a lot of work to be done before this approach might be used in the clinic， but we're hopeful that it will pave the way for new kinds of treatment for patients with sickle cell disease，" Corn said.
Sickle cell anemia is a blood disorder caused by a single mutation in both copies of a gene coding for beta-globin， a protein that forms part of the oxygen-carrying molecule hemoglobin.
This homozygous defect causes hemoglobin molecules to stick together， deforming red blood cells into a characteristic "sickle" shape. These misshapen cells get stuck in blood vessels， causing blockages， anemia， pain， organ failure and early death.
The disease is particularly prevalent in African Americans and the sub-Saharan African population， affecting hundreds of thousands of people worldwide.
The researchers also noted that the approach might also able used to develop treatments for other blood diseases， severe combined immunodeficiency， chronic granulomatous disease， rare disorders like Wiskott-Aldrich syndrome and Fanconi anemia， and even HIV infection.
"Sickle cell disease is just one of many blood disorders caused by a single mutation in the genome，" Corn said. "It's very possible that other researchers and clinicians could use this type of gene editing to explore ways to cure a large number of diseases."
"
JERUSALEM Wholesale Oklahoma City Thunder Jerseys , March 21 (Xinhua) -- Israel said on Monday it secretly brought 19 Jews out of Yemen, the last group who agreed to leave the war-ravaged country.
Seventeen Yemenite Jews arrived in Israel on Monday Wholesale Orlando Magic Jerseys , in addition to a couple who arrived a few days ago, the Jewish Agency Wholesale Philadelphia 76ers Jerseys , an Israel-based organization aimed at encouraging Jewish immigration to Israel, said.
According to a statement by the agency Wholesale Phoenix Suns Jerseys , the group comprises a family of five from Sanaa and 14 people from the town of Raydah in northwestern Yemen.
About 40-50 Jews still remain in Yemen, refusing to leave the country despite the ongoing civil war Wholesale Portland Trail Blazers Jerseys , it added.
Channel 2 TV news reported that the U.S. State Department helped coordinate the trip from Yemen, with which Israel has no diplomatic relations.
In 1949-1954 Wholesale Sacramento Kings Jerseys , Israel airlifted more than 50,000 Yemenite Jews out of Yemen and brought them to Israel in two secret operations Wholesale San Antonio Spurs Jerseys , but some Jews had decided to stay on inside Yemen.
""Today we bring that historic (immigration) mission to a close,"" Jewish Agency Chairman Natan Sharansky said in a statement. ""This is a very significant moment in the history of the state of Israel and for immigration to Israel.""
"
God blessed mankind with a lot of issues. The blessings of this life are numerous issues. Eyes are one of the most essential gifts of nature of us. But Wholesale Toronto Raptors Jerseys , because of today’s fast and competitive world, people have to function alot and this has been quite damaging for them. The overall wellness levels have fallen but some unique damage has been completed to eyes. Excessive reading and other things have made several defects to the eyes. Myopia is one of the main defects of eyes. This is a refractive disorder that is brought on by excessive reading. Some people were of the opinion that it is inherited but contemporary studies have revealed that it is really caused by too considerably reading and other things that strain the human eye. The laser technology has been utilized in several fields of life today and the use of laser in the medicine has been the most important and the most effective one too. The laser technology utilized in the eye surgery has produced such a convenience and ease that the hazards and disadvantages of the conventional eye surgery have been significantly eradicated. The laser for eyes has been profitable employed and laser for myopia has been treating patients successfully from across the globe.
Laser for eyes has been widely appreciated and laser for myopia has been regarded as the easiest way of therapy and surgery of the patient. The procedure of surgery is really basic. The principle is tohit the corneal layer with the laser. This laser has been given the name of excites laser. In the much more recent forms Wholesale Utah Jazz Jerseys , the corneal flap is cut and then the laser in incident and the surgery is accomplished on themapped areas. This allows the surgery to get completed successfully and the results are overwhelming. If the surgery gets performed successfully, the individual gets even much more than typical eyesig. Cheap Jerseys China Cheap Jerseys Online Cheap Wholesale Jerseys Cheap Jerseys China Wholesale Cheap Authentic Jerseys Cheap NCAA Jerseys Cheap Jerseys China Wholesale Cheap MLB Jerseys China Cheap Wholesale NFL Jerseys Cheap Jerseys China Free Shipping |
|
FAQ
Zoeken
Gebruikerslijst
Gebruikersgroepen
Registreren
Profiel
Log in om je privéberichten te bekijken
Inloggen
